Dynamic readout of nucleic acids by proteins
E-mail carolyn.thackrah@pharm.ox.ac.uk for joining instructions
Protein-ligand interactions are often considered as contacts of rigid bodies. Macromolecules, however, exhibit high degree of plasticity which can be used for their dynamic conformational readout. This readout greatly expands the repertoire of molecular recognition mechanisms but is also difficult to study. In this talk, I will present several examples of studies of dynamic conformational sampling of nucleic acids from various pathways including reverse transcription and DNA repair.
Date:
10 November 2020, 13:00 (Tuesday, 5th week, Michaelmas 2020)
Venue:
Online via Teams
Speaker:
Dr Marcin Nowotny (Laboratory of Protein Structure, International Institute of Molecular and Cell Biology, Warsaw)
Organising department:
Department of Pharmacology
Organiser:
Carolyn Thackrah (University of Oxford, Department of Pharmacology)
Organiser contact email address:
carolyn.thackrah@pharm.ox.ac.uk
Host:
Associate Professor Ming Lei (Department of Pharmacology, University of Oxford)
Part of:
Pharmacology, Anatomical Neuropharmacology and Drug Discovery Seminars
Booking required?:
Not required
Booking email:
carolyn.thackrah@pharm.ox.ac.uk
Audience:
Members of the University only
Editor:
Carolyn Thackrah
