'Deciphering the dialog between gut epithelial cells and mononuclear phagocytes' by Dr Ana-Maria Lennon-Dumenil
This seminar is open to members of the University of Oxford only. Please register with your University of Oxford email to ensure a successful registration. Registration is at: https://medsci.zoom.us/meeting/register/tJ0tcempqj0uEtFyn0bUrtwZhP8hpdDEW5Lt
Within tissues, dendritic cells constitute a complex cell population composed of distinct subsets that can exhibit different activation states and functions. How tissue-specific cues orchestrate dendritic cell diversification remains elusive. In the first part of my seminar, I will discuss unpublished results showing that, by reaching distinct sub-tissular niches within the gut, dendritic cells can exist as immature and mature cells, revealing a novel mechanism of dendritic cell functional diversification. In the second part of my seminar, I will present data highlighting the essential role of macrophages in protecting colonic epithelial cells from being poisoned by fungi toxins. I will discuss the implications of these findings on colon inflammation and cancer.
Date: 15 November 2021, 12:00 (Monday, 6th week, Michaelmas 2021)
Venue: Kennedy Institute of Rheumatology, Headington OX3 7FY
Venue Details: This seminar is open to members of the University of Oxford only. Please register with your University of Oxford email to ensure a successful registration. Registration is at: https://medsci.zoom.us/meeting/register/tJ0tcempqj0uEtFyn0bUrtwZhP8hpdDEW5Lt
Speaker: Dr Ana-Maria Lennon-Dumenil (Curie Institute)
Organising department: Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS)
Organisers: Dr Jelena Bezbradica (The Kennedy Institute of Rheumatology), Jennifer Pope (Kennedy Institute of Rheumatology), Professor Irina Udalova (Kennedy Institute of Rheumatology)
Organiser contact email address: reception@kennedy.ox.ac.uk
Host: Dr Audrey Gerard (The Kennedy Institute of Rheumatology)
Part of: Kennedy Institute Seminars
Booking required?: Required
Booking url: https://medsci.zoom.us/meeting/register/tJ0tcempqj0uEtFyn0bUrtwZhP8hpdDEW5Lt
Audience: Members of the University only
Editors: Jennifer Pope, Ellen Mobbs