This presentation will introduce the multiphase optimization trial (MOST), an engineering-inspired framework for developing, optimizing, and evaluating multicomponent behavioral, biobehavioral, and biomedical interventions. Optimization is the process of identifying an intervention that attains the best expected outcomes given key constraints imposed by the need for affordability, scalability, and/or efficiency. The presentation will provide an overview of the application of MOST to a number of public health priorities and offer a vision for the future of intervention science.