Mindfulness-based programs (MBPs) are frequently customized to meet specific patient and population groups, but little is known about frameworks and methods for MBP customization that could be consistently utilized in the field across a variety of health conditions and demographic populations. This presentation will provide an overview of frameworks used for customization in specific health conditions (e.g. hypertension in the Mindfulness-Based Blood Pressure Reduction study) and demographics (e.g. emerging adults aged 18-29 years in the Mindfulness-Based College study). Discussion will focus on these and other customization frameworks, such as for Mindfulness-Based Cognitive Therapy.