The hitchhiker's guide to complex models of intracellular signalling
Unraveling the intricacies of intracellular signalling through predictive mathematical models holds great promise for advancing precision medicine and enhancing our foundational comprehension of biology. However, navigating the labyrinth of biological mechanisms governing signalling demands a delicate balance between a faithful description of the underlying biology and the practical utility of parsimonious models.
In this talk, I will present methods that enable training of large ordinary differential equation models of intracellular signalling and showcase application of such models to predict sensitivity to anti-cancer drugs. Through illustrative examples, I will demonstrate the application of these models in predicting sensitivity to anti-cancer drugs. A critical reflection on the construction of such models will be offered, exploring the perpetual question of complexity and how intricate these models should be.
Moreover, the talk will explore novel approaches that meld machine learning techniques with mathematical modelling. These approaches aim to harness the benefits of simplistic and unbiased phenomenological models while retaining the interpretability and biological fidelity inherent in mechanistic models.
Date: 26 January 2024, 14:00 (Friday, 2nd week, Hilary 2024)
Venue: Mathematical Institute, Woodstock Road OX2 6GG
Venue Details: L3
Speaker: Professor Fabian Frohlich (The Francis Crick Institute)
Organising department: Mathematical Institute
Part of: Mathematical Biology and Ecology
Booking required?: Not required
Audience: Members of the University only
Editor: Sara Jolliffe