Understanding and managing acquired leukocyte dysfunction in critical illness
This is a hybrid event - with the speaker attending in-person and viewable on Teams.
Around 50% of patients admitted to intensive care units (ICUs) develop an acquired innate immune dysfunction related to the severity of their underlying presentation. This increases the risk of secondary infection in the ICU, which drives pressures to prescribe antibiotics, which in turn encourages the emergence of antimicrobial resistance.

The talk will primarily consider potential mechanisms underlying the critical illness-induced dysfunction in neutrophils and how these suggest therapeutic targets, finishing with a description of clinical trials we are about to start, ultimately seeking to translate our work into a non-antibiotic-based strategy for reducing ICU-acquired infection.
Date: 6 March 2023, 13:00 (Monday, 8th week, Hilary 2023)
Venue: MRC Weatherall Institute of Molecular Medicine, Headington OX3 9DS
Venue Details: WIMM Seminar Room and via Teams
Speaker: Professor John Simpson (Director of the NIHR-Newcastle In Vitro Diagnostics Co-operative)
Organising department: MRC Weatherall Institute of Molecular Medicine
Organiser: Karen Brown (Weatherall Institute, University of Oxford)
Organiser contact email address: seminar.admin@imm.ox.ac.uk
Host: Professor Paresh Vyas (University of Oxford, Weatherall Institute of Molecular Medicine)
Part of: WIMM MONDAY SEMINARS
Booking required?: Required
Booking email: seminar.admin@imm.ox.ac.uk
Audience: Members of the University only
Editors: Karen Brown, Calvin Chau, Jenna Hughes-Jones, Selena Geerts, Emma Brayne, Nicole Harris