The order Picornavirales comprises of several virus families which infect humans, animals and insects. Even though all viruses in this order are icosahedrally-symmetric and are made of three capsid proteins, there are several distinct features found in their capsids. Additionally, the capsid assembly was thought to be conserved across virus families. However, our recent work suggests otherwise.

I will discuss two examples, human parechovirus (family: Picornaviridae) and norovirus (family: Dicistoviridae) from the order Picornavirales whose structures and assemblies do not follow not so common path.