Seminar by Prof Andrew MacDonald "Dendritic cells and macrophages in promotion and regulation of pulmonary type-2 inflammation"
We are returning to in person seminars in the Kennedy Institute Lecture Theatre with the option to join using Zoom https://medsci.zoom.us/meeting/register/tJUudOmqrT0rGNEn7PN_OZusszbQ19vfI9tO
Fine control of immune cell activation is critical for preventing inflammatory disease, particularly in barrier sites such as the lung. However, the central mechanisms involved in controlling pulmonary macrophages and dendritic cells (DCs) during type-2 inflammation are currently poorly understood. We have found that the lung environment dramatically impairs the ability of alveolar macrophages to respond during type-2 inflammation following administration of IL-4 complex (IL-4c), allergen exposure or helminth infection, and identified which DC subpopulations are associated with induction of type-2 outcomes in such settings. Together, our data provide novel insight into the fundamental mechanisms that control macrophage and DC activation and function during pulmonary type-2 inflammation.
Date: 4 July 2022, 12:00 (Monday, 11th week, Trinity 2022)
Venue: Kennedy Institute of Rheumatology, Headington OX3 7FY
Venue Details: We are returning to in person seminars in the Kennedy Institute Lecture Theatre with the option to join using Zoom https://medsci.zoom.us/meeting/register/tJUudOmqrT0rGNEn7PN_OZusszbQ19vfI9tO
Speaker: Prof Andrew MacDonald (University of Manchester)
Organising department: Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS)
Organisers: Ellen Mobbs (Kennedy Institute of Rheumatology), Dr Jelena Bezbradica (The Kennedy Institute of Rheumatology), Professor Irina Udalova (Kennedy Institute of Rheumatology)
Organiser contact email address: ellen.mobbs@kennedy.ox.ac.uk
Host: Dr Jethro Johnson (The Kennedy Institute of Rheumatology)
Part of: Kennedy Institute Seminars
Booking required?: Required
Booking url: https://medsci.zoom.us/meeting/register/tJUudOmqrT0rGNEn7PN_OZusszbQ19vfI9tO
Audience: Members of the University only
Editors: Elizabeth Thompson, Ellen Mobbs