Neurovascular interactions during CNS development
The development of the nervous and the vascular systems exhibit extensive similarities, both on the anatomical and the molecular level. Blood vessels and nerves are structurally similar and often aligned, following parallel routes. The brain is the most vascularized tissue in our body. In the past, we have discovered that the same molecular mechanisms are used to orchestrate the development of the nervous and the vascular system. It is now believed that blood vessels in the brain exert instructive functions that go beyond supplying nutrients and oxygen, for example supplying ligands that directly influence neuronal behavior by activating corresponding receptors and signaling pathways in neuronal cells. We are interested in elucidating the molecular pathways involved in the crosstalk between vessels and nerves and how this crosstalk signaling is integrated among the different cellular players (neurons, endothelial cells, astrocytes) at the neurovascular interface during CNS development and during adult functions such as blood brain barrier maintenance and synaptic plasticity.
References:
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Date:
18 October 2019, 13:00 (Friday, 1st week, Michaelmas 2019)
Venue:
Sherrington Building, off Parks Road OX1 3PT
Venue Details:
Large Lecture Theatre
Speaker:
Professor Amparo Acker-Palmer (Institute of Cell Biology and Neuroscience, Buchmann Institute for Molecular Life Sciences (BMLS), Johann Wolfgang Goethe-University, Frankfurt)
Organising department:
Department of Physiology, Anatomy and Genetics (DPAG)
Organiser:
Professor Maike Glitsch (DPAG, University of Oxford)
Organiser contact email address:
hod-pa@dpag.ox.ac.uk
Host:
Professor Maike Glitsch (DPAG, University of Oxford)
Part of:
DPAG Head of Department Seminar Series
Booking required?:
Not required
Audience:
Members of the University only
Editor:
Talitha Smith
