Biochemical Dissection of Autophagy
This seminar will be held using Zoom. Please register here: https://zoom.us/meeting/register/tJwvdeyprTgtH9SYZpmfzQ7fNu-LA1vIxi41
Autophagy is a highly regulated cellular degradation system that engulfs cytosol, organelles, protein aggregates and invading microorganisms into a double-membrane vesicle termed the autophagosome, then delivers cargo to endolysosomes for degradation. Autophagy dysfunction has been implicated in a broad spectrum of human diseases, including cancers, neurodegeneration, infectious diseases, metabolic diseases and aging. My lab focuses on the biochemical mechanisms of autophagosome biogenesis, substrate recruitments and autophagosome fusion with lysosomes. We have identified and characterized novel protein factors (ATG14, NRBF2, TECPR1, OFD1 etc.,) essential for autophagy initiation, cargo recruitment and autophagosome-lysosome fusion (PNAS 2008,2010, 2012, Nature 2013, 2015, Mol Cell 2012).
Date: 13 July 2020, 10:00 (Monday, 12th week, Trinity 2020)
Venue: Kennedy Institute of Rheumatology, Headington OX3 7FY
Venue Details: This seminar will be held using Zoom. Please register here: https://zoom.us/meeting/register/tJwvdeyprTgtH9SYZpmfzQ7fNu-LA1vIxi41
Speaker: Professor Qing Zhong (Shanghai Jiaotong University School of Medicine, China)
Organising department: Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS)
Organiser: Jennifer Pope (Kennedy Institute of Rheumatology)
Organiser contact email address: jennifer.pope@kennedy.ox.ac.uk
Host: Professor Katja Simon ((Kennedy Institute) University of Oxford)
Part of: Kennedy Institute Seminars
Booking required?: Required
Booking url: https://zoom.us/meeting/register/tJwvdeyprTgtH9SYZpmfzQ7fNu-LA1vIxi41
Audience: Members of the University only
Editor: Jennifer Pope