The De Miranda lab is interested in uncovering the mechanisms that drive neurologic disease from environmental exposures. They are currently investigating chlorinated solvents, such as the degreasing compound trichloroethylene (TCE), and their role in dopaminergic neurodegeneration in Parkinson’s disease. They take a system wide approach to address these mechanisms – including understanding how route of exposure can influence neurotoxicity and disease phenotype (e.g., cognitive dysfunction).

In addition to solvents, we undertake projects assessing how pesticides, metals, and other neurotoxic contaminants induce oxidative stress, impair mitophagy/autophagy, and influence neuroinflammation. Our overall goal is to mitigate toxicity with therapeutic interventions or environmental remediation efforts.