How cells defend their cytosol against bacteria: LPS ubiquitylation and other tricks
In-person
Intracellular pathogens colonize specific subcellular niches, determined by their need for host-derived nutrients and their ability to overcome compartment-specific immune responses. Most intracellular bacteria reside in phagosomes, with only a few species managing to colonize the cytosol. This is somewhat counterintuitive, given the abundance of nutrients freely available in the cytosol. Therefore, potent cytosolic defense mechanisms must exist. I will discuss how cells protect their cytosol against bacterial invasion through autophagy, focusing on novel triggers for antibacterial autophagy that we have discovered: the detection of sphingomyelin on damaged phagosomes by TECPR1, and the ubiquitylation of LPS on Gram-negative bacteria by RNF213. I will also explore how cytosol-adapted bacteria counteract antibacterial autophagy
Date:
13 January 2025, 12:00
Venue:
Kennedy Institute of Rheumatology, Headington OX3 7FY
Venue Details:
Kennedy Lecture Theatre
Speaker:
Dr Felix Randow (MRC Laboratory of Molecular Biology, Cambridge, UK)
Organising department:
Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS)
Organisers:
Katie Roberts (University of Oxford),
Jo Silva (NDORMS)
Organiser contact email address:
katie.roberts@kennedy.ox.ac.uk
Host:
Jelena Bezbradica Mirkovic (KTRR SENIOR RESEARCH FELLOW)
Part of:
Kennedy Institute Seminars
Booking required?:
Not required
Audience:
Members of the University only
Editor:
Katie Roberts
