Characterising human proteome diversity in health and disease
Professor Angus I. Lamond FRS FRSE FMed Sci is an RNA biochemist and molecular cell biologist working at the University of Dundee, School of Life Sciences. Angus has a PhD from the University of Cambridge, where he worked on the regulation of bacterial transcription at the L.M.B. As a postdoctoral fellow with Phillip Sharp in the Center for Cancer Research at M.I.T., Angus began working on RNA processing and the mechanism of pre-mRNA splicing in human cells. As a group leader at the European Molecular Biology Laboratory in Heidelberg, Angus continued working on biochemical mechanisms involved in RNA processing and alternative splicing, which led on to him studying the functional organisation of subnuclear bodies in mammalian cells, aiming to understand how nuclear structure coordinates the processing of pre-mRNAs and pre-rRNAs. While at EMBL, he was introduced by Matthias Mann to the analysis of proteins using mass spectrometry and in collaboration with the Mann group pioneered the proteomic analysis of RNA processing complexes and nuclear bodies. Since moving to the University of Dundee, the Lamond group have continued to study mechanisms involved in alternative splicing and human disease, using a combination of methods spanning quantitative proteomics, microscopy and in vitro biochemical assays. The Lamond group also study the impact of human genetic diversity at the protein level and how this affects cellular phenotypes and disease mechanisms.
Date:
4 October 2024, 14:00 (Friday, -1st week, Michaelmas 2024)
Venue:
Sir William Dunn School of Pathology, South Parks Road OX1 3RE
Venue Details:
EPA Seminar room
Speaker:
Prof Angus Lamond (University of Dundee)
Organising department:
Sir William Dunn School of Pathology
Organiser:
Melissa Wright (Sir William Dunn School of Pathology)
Organiser contact email address:
melissa.wright@path.ox.ac.uk
Host:
Dr Girish Mali (Dunn School of Pathology)
Part of:
Dunn School of Pathology Departmental Seminars
Booking required?:
Not required
Audience:
Members of the University only
Editor:
Melissa Wright
