Role in cell-membrane organization of protein-protein interactions mediated by the membrane
I present recent advances in the understanding of how inter-protein forces, notably those propagated by the elastic membrane (depletion forces, hydrophobic mismatch forces, wetting forces, forces of entropic origin, etc.), shape the plasma membrane by promoting the existence of nanodomains in thermodynamical equilibrium. By modulating short-range affinities of different protein species, I show how these domains become specialized on the biological level by aggregating few protein species. I also discuss how thermodynamic equilibrium is affected when membrane-recycling is switched on, thus driving the membrane out of equilibrium.
Date:
28 September 2017, 15:00 (Thursday, -1st week, Michaelmas 2017)
Venue:
Sir William Dunn School of Pathology, South Parks Road OX1 3RE
Venue Details:
EPA Seminar Room
Speaker:
Prof. Nicolas Destainville (Université Toulouse III-Paul Sabatier/CNRS)
Organising department:
Sir William Dunn School of Pathology
Organiser:
Melissa Wright (Sir William Dunn School of Pathology)
Organiser contact email address:
melissa.wright@path.ox.ac.uk
Host:
Professor Oreste Acuto (Sir William Dunn School of Pathology)
Part of:
Dunn School of Pathology Research Seminars
Booking required?:
Not required
Audience:
Members of the University only
Editor:
Melissa Wright
