Guidance cue code for B cell immunity
In-person
Multiple tightly orchestrated cell migration events underlie every B cell response. Our work on chemokines and lipid mediators supporting T-dependent B cell responses will be reviewed. This will include updates on the human germinal center confinement receptor P2RY8, and the adhesion GPCR, CD97, and its role in dendritic cell and B cell positioning in the spleen. Early during inflammation, CCL21 is downregulated in lymph nodes, yet B and T cell recruitment continues, and this is important to ensure sufficient precursors are present to respond. We find that inflammation switches the chemoattractant code for naïve lymphocyte entry into lymph nodes. Our ongoing work on this topic will be presented.
Date:
27 February 2025, 12:00
Venue:
Kennedy Institute of Rheumatology, Headington OX3 7FY
Venue Details:
Kennedy Lecture Theatre
Speaker:
Professor Jason Cyster (University of California)
Organising department:
Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS)
Organiser:
Katie Roberts (University of Oxford)
Host:
Prof Mark Coles (Kennedy Institute of Rheumatology )
Part of:
Kennedy Institute Seminars
Booking required?:
Not required
Audience:
Members of the University only
Editor:
Katie Roberts
