For our next talk, in the BDI/CHG (gen)omics Seminar series, we will be hearing from Prof James Davies, Group Leader, MRC Weatherall Institute of Molecular Medicine. We’re delighted to host James in what promises to be a great talk!
Talk title: Defining genome structure at base pair resolution
Date: Tuesday 21 January
Time: 9:30 am – 10:30 am
Location: Big Data Institute, Seminar Room 1
Bio: James Davies is a group leader at the MRC Weatherall Institute of Molecular Medicine and a practicing clinician with a specialist interest in bone marrow transplantation and cellular therapy. His research group’s primary focus is deciphering how the genome is interpreted by different cell types. They leverage this to develop methods for using genome editing technology to manipulate bone marrow stem cells, with the aim of treating diseases of the blood and immune system.
Abstract: DNA structure within the nucleus is a key determinant of gene expression in eukaryotes and it allows many genes to be controlled by multiple regulatory elements that are often separated by large distances in the linear genome sequence. It has not previously been possible to define the structure and interactions of cis-regulatory elements at the scale of the proteins that bind them. We have developed a new technique (Micro Capture-C ultra (MCCu)), which allows multidimensional chromosome conformation capture (3C) maps to be generated at base-pair resolution (around 50-fold better than previous studies). To understand how the biophysical properties of chromatin drive structure we have used chemically specific coarse-grained molecular dynamics simulations of chromatin, which model the biophysical properties of nucleosomes and DNA. We have subsequently gone on to develop methods of using chromatin structure to interrogate how distal regulatory sequences alter disease susceptibility in the humans. This approach allows novel genes to be identified that are associated with human disease.
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All members of the University are welcome to join, please let reception at BDI know you’re here for the seminar and sign-in. We hope you can join us!
We also now have a mailing list –
To be added, ping genomics_bdi_whg-subscribe@maillist.ox.ac.uk (with any message), you should get a bounce-back with three options to confirm your subscription. Follow any of those options, and with a bit of luck you should be signed up!
As a reminder, the (gen)omics seminar series runs every other Tuesday morning and is intended to increase interaction between individuals working in genomics across Oxford. We encourage in-person attendance where possible. There is time for discussion over, tea, coffee and pastries after the talks.
Hybrid Option:
Please note that these meetings are closed meetings and only open to members of the University of Oxford to encourage sharing of new and unpublished data. Please respect our speakers and do not share the link with anyone outside of the university.
Microsoft Teams meeting –
Meeting ID: 331 901 849 825
Passcode: ih9MK7zJ
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