This lecture brings contemporary art by Chicana (Mexican American) women artists into dialogue with the seventeenth and eighteenth centuries, collapsing and questioning art history’s chronological and geographical frameworks and borders. I examine portrayals of Sor Juana Inés de la Cruz (1648-1695), famed writer, intellectual, and proto-feminist nun in colonial Mexico. How can recent visual imaginings by Chicana feminist artists illuminate earlier, historical portrayals of Mexico’s “Tenth Muse”? Can the tools of Chicanx studies force a reconceptualization of art history?