The genetics of depression are advancing at an exponential rate – now we are turning to how genetics can inform prediction and biology. The Genetics Links to Anxiety and Depression or GLAD study is the world’s largest study of severe depression and anxiety. We have conducted joint family history, polygenic scores, and trauma prediction modelling and have developed a strong predictor of major depressive disorders status and clinically relevant outcomes like number of episodes and age of onset — with replication and validation of this model in UK Biobank. Turning to Eating Disorders, these have much stronger genetic risks than depression and I will present our latest analyses from the psychiatric genomic consortium for anorexia nervosa and binge eating behaviour in >23K cases of anorexia and >35,000 cases with either binge eating disorder or binge eating behaviour. Lastly, I will briefly outline our current efforts to Nanopore whole genome sequence 22K samples in the NIHR Bioresource, including 4K eating disorder cases.

Zoom details:

zoom.us/j/98643323773?pwd=bL0TW4vweAlQzIlL5VEFHKYiEaVYPl.1
Meeting ID: 986 4332 3773
Passcode: 758174