Host microbiome interactions in health and disease
Professor Eran Elinav: Host microbiome interactions in health and disease
The mammalian intestine contains trillions of microbes, a community that is dominated by members of the domain Bacteria but also includes members of Archaea, Eukarya, and viruses. The vast repertoire of this microbiome functions in ways that benefit the host. The mucosal immune system co-evolves with the microbiota beginning at birth, acquiring the capacity to tolerate components of the community while maintaining the capacity to respond to invading pathogens. The gut microbiota is shaped and regulated by multiple factors including our genomic composition, the local intestinal niche and multiple environmental factors including our nutritional repertoire and bio-geographical location. Moreover, it has been recently highlighted that dysregulation of these genetic or environmental factors leads to aberrant host-microbiome interactions, ultimately predisposing to pathologies ranging from chronic inflammation, obesity, the metabolic syndrome and even cancer. We have identified various possible mechanisms participating in the reciprocal regulation between the host and the intestinal microbial ecosystem, and demonstrate that disruption of these factors, in mice and humans, lead to dysbiosis and susceptibility to common multi-factorial disease. Understanding the molecular basis of host-microbiome interactions may lead to development of new microbiome-targeting treatments.
Date:
19 November 2020, 17:00 (Thursday, 6th week, Michaelmas 2020)
Venue:
This talk will be hosted online
Speaker:
Professor Eran Elinav (Weizmann Institute of Science)
Organising department:
Wellcome Trust Centre for Human Genetics
Organisers:
Catherine Lidbetter (Centre for Personalised Medicine),
Thea Perry (Centre for Personalised Medicine)
Organiser contact email address:
cpm@well.ox.ac.uk
Hosts:
Catherine Lidbetter (Centre for Personalised Medicine),
Thea Perry (Centre for Personalised Medicine)
Part of:
Centre for Personalised Medicine Seminars
Booking required?:
Required
Booking url:
https://us02web.zoom.us/meeting/register/tZEkd-uhrTsiGN23XbOBgPrkGlAzhL59ukk5
Cost:
Free
Audience:
Public
Editor:
Thea Perry
