Mutant phosphodiesterase 3A protects from hypertension-induced cardiac damage
Please note this seminar has been rescheduled to Friday 28 October
Gain-of-function mutations in the gene encoding phosphodiesterase (PDE) 3A cause hypertension with brachydactyly (HTNB). If the hypertension is not treated, the patients die of stroke by the age of 50 years. Even treated, the blood pressure does not reach physiological levels. Surprisingly, despite the decade-long hypertension, HTNB patients do not show cardiac damage. The presentation comprises an introduction of HTNB and will show analyses of HTNB rat and cell-based models, which suggest mechanisms accounting for the cardioprotection of the mutations.
Date: 28 October 2022, 13:00 (Friday, 3rd week, Michaelmas 2022)
Venue: Sherrington Building, off Parks Road OX1 3PT
Venue Details: Florence Buchanan Lecture Theatre (second floor)
Speaker: Dr Enno Klussmann (Max-Delbrück-Centrum für Molekulare Medizin, Berlin)
Organising department: Department of Physiology, Anatomy and Genetics (DPAG)
Organiser: Professor Manuela Zaccolo MD (DPAG, University of Oxford)
Organiser contact email address: manuela.zaccolo@balliol.ox.ac.uk
Host: Professor Manuela Zaccolo MD (DPAG, University of Oxford)
Part of: Cardiac Sciences Theme Guest Speakers
Booking required?: Not required
Audience: Members of the University only
Editor: Talitha Smith