Structures of Dengue and Zika viruses
Dengue and Zika virus are members of the family flaviviridae and are major
human pathogens. These viruses are mainly spread to humans via the bit of
an infected mosquitoes, although Zika virus can also be transmitted by
sexual contact. Both dengue and zika virus particles are made up of only 3
proteins. Dengue virus has been shown to exhibit tremendous structural
flexibility during their infection cycle. Here we will describe the
structural changes of the surface proteins of dengue virus in different
hosts and at different stages of infection in the cell. We will also
describe the structure of mature Zika virus and relate the findings to its
observed increase in thermo-stability compared to dengue virus.
Date: 16 September 2016, 11:00 (Friday, 21st week, Trinity 2016)
Venue: Wellcome Trust Centre for Human Genetics, Headington OX3 7BN
Venue Details: Meeting Room A/B
Speaker: Prof Shee-Mei Lok (Duke-NUS Medical School in Singapore)
Organising department: Wellcome Trust Centre for Human Genetics
Organiser: Agata Krupa (Wellcome Trust Centre for Human Genetics)
Organiser contact email address: grunewald-pa@strubi.ox.ac.uk
Host: Prof Juha Huiskonen (University of Oxford )
Part of: Strubi seminars
Booking required?: Not required
Audience: Members of the University only
Editor: Agata Krupa