The fast and the curious: High-throughput in vivo identification of synthetic gene therapy vectors
Adeno-associated virus (AAV) forms the basis of one of the most promising and most versatile vector systems for therapeutic human gene transfer, owing to a unique combination of apathogenicity and low immunogenicity, paired with high amenability to genetic engineering and repurposing of the viral capsid and genome. This presentation will introduce an assortment of key technologies for targeted modification and directed evolution of critical AAV components, with a particular focus on their application on the large scale and on the high-throughput selection of ensuing capsid or promoter libraries in animals.
Date: 16 February 2024, 15:00 (Friday, 5th week, Hilary 2024)
Venue: IMS-Tetsuya Nakamura Building, Roosevelt Dr, Headington OX3 7TY
Venue Details: IDRM Seminar Rooms
Speaker: Professor Dirk Grimm (University of Heidelberg)
Organising department: Medical Sciences Division
Host: Dr Rebecca Berrens (Department of Paediatrics)
Booking required?: Required
Booking url: https://forms.office.com/e/fApjyb5p09
Audience: Members of the University only
Editor: Amanda Nicolle