'Macrophage Membrane Domains that Coordinate Toll-like Receptor Signaling'
Special Visiting Scientist seminar
Toll-like receptor (TLR) signaling controls inflammation in macrophages by tailoring programs of inflammatory cytokines. TLR-induced inflammation is constrained by Rab GTPases and PI3Ks that modulate Akt and mTOR signaling, while proinflammatory cytokine production is promoted by transmembrane adaptor complexes and SFKs. These molecules operate in the context of high turnover, highly dynamic membranes of dorsal ruffles and macropinosomes at the macrophage surface, viewed in live cells by lattice light sheet imaging and other imaging modalities. Coordinated assembly of membrane domains and signaling pathways provides exquisite orchestration of inflammation and innate immune responses.
Date:
17 May 2018, 11:00 (Thursday, 4th week, Trinity 2018)
Venue:
Kennedy Institute of Rheumatology, Headington OX3 7FY
Venue Details:
Bernard Sunley Lecture Theatre
Speaker:
Prof Jennifer Stow (University of Queensland)
Organising department:
Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS)
Organiser:
Jelena Bezbradica Mirkovic (KTRR SENIOR RESEARCH FELLOW)
Organiser contact email address:
reception@kennedy.ox.ac.uk
Host:
Jelena Bezbradica Mirkovic (KTRR SENIOR RESEARCH FELLOW)
Booking required?:
Not required
Audience:
Members of the University only
Editor:
Abigail Ludlow
