Engineering extracellular microenvironment through Intravital 3D bioprinting
Research in the Elvassore laboratory combines engineering principles with basic biological science to rationally understand the mechanisms governing cell and tissue behavior. We developed reprogramming of human somatic cells to hiPSCs with high efficiency using microfluidics. We showed that nascent states of pluripotency, naïve and primed, have full developmental potential in three-dimension (3D), which enables the morphogenesis of functional organoids. We developed intravital 3D bioprinting technology to control, in space and time, the narrative design of 3D culture systems, acting on the ECM architecture. This intravital technology will also provide an unprecedented tool to control organoid shape in vivo, as well as to quantify mechanical forces at the tissue scale during vertebrate morphogenesis.
Date: 2 December 2022, 13:00 (Friday, 8th week, Michaelmas 2022)
Venue: Sherrington Building, off Parks Road OX1 3PT
Venue Details: Blakemore Lecture Theatre
Speaker: Professor Nicola Elvassore (Developmental Biology & Cancer Department, UCL GOS Institute of Child Health)
Organising department: Department of Physiology, Anatomy and Genetics (DPAG)
Organisers: Dr Mootaz Salman (DPAG, University of Oxford), Dr Armin Lak (DPAG, University of Oxford)
Organiser contact email address: hod-pa@dpag.ox.ac.uk
Host: Prof Francis Szele (DPAG, University of Oxford)
Part of: DPAG Head of Department Seminar Series
Booking required?: Not required
Audience: Members of the University only
Editor: Talitha Smith