I will present metabolomics & lipidomics methods touching on data accuracy and implications for biomarker discovery. Will show clinical examples in different tissues, ie. patient stratification with metabolomics (plasma in diabetes), biomarkers (liver tissue before transplantation) and the healthy metabolic baseline (fecal samples).

I will follow up with research designed to find early biomarkers (brain, CSF, plasma) and mechanisms in Alzheimer’s Disease, focusing on experimental design, data reduction examples, feature selection and validation together with integration with -omics (proteomics & genomics).