Closed-loop modulation of neural activity at different timescales
I shall describe three approaches to manipulate the activity of neural circuits in closed loop. (i) By modulating illumination intensity as a function of the local field potential we can use optogenetics to achieve dissociable control of the phase, amplitude and frequency of gamma oscillations. (ii) We have shown that viral expression of a glutamate-sensitive chloride channel both suppresses seizures and rescues comorbidities in a mouse model of temporal lobe epilepsy. (iii) By placing a potassium channel under the control of an immediate early gene promoter, we can selectively inhibit overactive neurons without affecting intermingled neurons, a potentially versatile approach to treat disorders of circuit hyperactivity.
Date:
17 July 2024, 15:00 (Wednesday, 13th week, Trinity 2024)
Venue:
Pharmacology, off Mansfield Road OX1 3QT
Venue Details:
Pharmacology Lecture Theatre
Speaker:
Prof. Dimitri Kullman (University College London)
Organising department:
MRC Brain Network Dynamics Unit
Organiser:
Prof. Andrew Sharott (MRC Brain Network Dynamics Unit)
Organiser contact email address:
andrew.sharott@bndu.ox.ac.uk
Host:
Professor David Dupret (Nuffield Department of Clinical Neurosciences, University of Oxford)
Part of:
Brain Network Dynamics Seminar Series
Booking required?:
Not required
Audience:
Members of the University only
Editor:
Andrew Sharott
