Our lab studies the germline cycle in vivo in mammalian embryos, and also in vitro using primary culture systems and pluripotent stem cell models. By studying how pluripotency is regulated both in vivo and in vitro we seek to answer basic questions about the regulation of cell fate and potency.

By studying basic questions in stem cell biology, developmental biology, epigenetics and reproduction we hope to inform the treatment of human infertility, such as by in vitro gametogenesis approaches, and more broadly impact the field of regenerative medicine.