Adapting protein quality control for intervention in immunity and neurodegenerative diseases
please arrive 5 minutes before the seminar to gain entry to the building
Protein folding is tightly regulated by molecular chaperones and other protein quality control mechanisms such as the ubiquitin proteasome system and autophagy to ensure the integrity of the proteome. However, these systems can fail to prevent protein misfolding, leading to protein aggregation and amyloidosis. They are underlying reasons for many neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease or Huntington’s disease. Interfering with protein quality control systems and modulating posttranslational modifications of proteins can reduce aggregation, ameliorate amyloidosis and can have profound effects on the immune system.
Date:
21 November 2018, 12:00
Venue:
Medawar Building, off South Parks Road OX1 3SY
Venue Details:
Level 30 Seminar Room
Speaker:
Heidi Olzscha (University of Halle-Wittenberg)
Organising department:
Nuffield Department of Clinical Medicine
Organisers:
Professor Sunetra Gupta (University of Oxford),
Prof Lynn Dustin (NDORMS)
Organiser contact email address:
thomas.johnson@tss.ox.ac.uk
Host:
Professor Sunetra Gupta (University of Oxford)
Part of:
Peter Medawar Building Seminars
Topics:
Booking required?:
Not required
Cost:
FREE
Audience:
Members of the scientific community
Editor:
Thomas Johnson
