Simple, scalable, and interpretable risk stratification in psychiatry using electronic health records
With the emergence of evidence-based treatments for treatment-resistant depression, strategies to identify individuals at greater risk for treatment resistance early in the course of illness could have clinical utility. We sought to develop and validate a model to predict treatment resistance in major depressive disorder using coded clinical data from the electronic health record. We identified individuals from a large health system with a diagnosis of major depressive disorder receiving an index antidepressant prescription, and used a tree-based machine learning classifier to build a risk stratification model to identify those likely to experience treatment resistance. The resulting model was validated in a second health system.

Electronic health records facilitated stratification of risk for treatment-resistant depression and demonstrated generalizability to a second health system. Efforts to improve upon such models using additional measures, and to understand their performance in real-world clinical settings, are warranted.
Date: 26 April 2022, 15:00 (Tuesday, 1st week, Trinity 2022)
Venue: via Zoom (please email to get a link or consider subscribing to mailing list here: web.maillist.ox.ac.uk/ox/info/ai4mch)
Speaker: Professor Roy H. Perlis (Harvard Medical School)
Organising department: Department of Psychiatry
Organiser: Dr Andrey Kormilitzin (University of Oxford)
Organiser contact email address: andrey.kormilitzin@psych.ox.ac.uk
Host: Dr Andrey Kormilitzin (University of Oxford)
Part of: Artificial Intelligence for Mental Health Seminar Series
Booking required?: Recommended
Booking url: https://web.maillist.ox.ac.uk/ox/info/ai4mch
Booking email: andrey.kormilitzin@psych.ox.ac.uk
Audience: Public
Editor: Andrey Kormilitzin