Adipocytes in the melanoma microenvironment – insights from zebrafish models of cancer
Zebrafish models of cancer have emerged as powerful tools to image cancer progression and metastasis. When coupled with the robust genetic tools available in the model, it is an ideal system to dissect the in vivo interactions between tumor cells and their surrounding microenvironment. In a screen for stromal factors supporting melanoma outgrowth, we have identified signals from the surrounding adipocytes as being major drivers of melanoma progression. The seminar will discuss the nature of the melanoma-adipocyte interactions including novel ways of interrupting this cross-talk.
Date: 23 March 2017, 11:00 (Thursday, 10th week, Hilary 2017)
Venue: NDM Building, Headington OX3 7FZ
Venue Details: Basement seminar room (please note, not ORCRB)
Speaker: Professor Richard White (Sloan Kettering, New York)
Organising department: Ludwig Institute for Cancer Research, Oxford Branch
Organiser: Mary Muers (Oxford Ludwig Institute, NDM Experimental Medicine)
Organiser contact email address: christina.woodward@ludwig.ox.ac.uk
Host: Prof Colin Goding (Ludwig Cancer Research, University of Oxford)
Part of: Ludwig Institute Seminar Series
Booking required?: Not required
Audience: Members of the University only
Editors: Mary Muers, Christina Woodward