Mathematical models of targeted cancer therapies
The talk will discuss the use of mathematical models for understanding targeted cancer therapies. One area of focus is the treatment of chronic lymphocytic leukemia with tyrosine kinase inhibitors. I will explore how mathematical approaches have helped elucidate the mechanism of action of the targeted drug ibrutinib, and will discuss how evolutionary models, based on patient-specific parameters, can make individualized predictions about treatment outcomes. Another focus of the talk is the use of oncolytic viruses to kill cancer cells and drive cancers into remission. These are viruses that specifically infect cancer cells and spread throughout tumors. I will discuss mathematical models applied to experimental data that analyze virus spread in a spatially structured setting, concentrating on the interactions of the virus with innate immune mechanisms that determine the outcome of virus spread.
Date:
19 February 2021, 14:00 (Friday, 5th week, Hilary 2021)
Venue:
Mathematical Institute, Woodstock Road OX2 6GG
Speaker:
Professor Dominik Wodarz (University of California Irvine)
Organising department:
Mathematical Institute
Organiser:
Sara Jolliffe (University of Oxford)
Organiser contact email address:
sara.jolliffe@maths.ox.ac.uk
Host:
Prof Ruth Baker (University of Oxford)
Part of:
Mathematical Biology and Ecology
Booking required?:
Not required
Audience:
Members of the University only
Editor:
Sara Jolliffe
