Molecular and spatial control of tumor-associated macrophages
In person
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer marked by severe immune suppression and abnormal inflammation that promote tumor growth. Recent research identified IL-1b+ tumor-associated macrophages (TAMs) as a subset that drives inflammatory changes and influences nearby tumor cells. Using spatial gene expression analysis we explored the physical distribution and local interactions of IL-1b+ TAMs and within human PDAC tissue. The findings revealed distinct clustering of immune and non-immune cells into specific multicellular hubs, suggesting potential immune-mediated pathways that could be targeted for therapeutic strategies.
Date: 2 December 2024, 12:00 (Monday, 8th week, Michaelmas 2024)
Venue: Kennedy Institute of Rheumatology, Headington OX3 7FY
Venue Details: Lecture Theatre
Speaker: Prof Renato Ostuni (San Raffaele Telethon Institute, Milan)
Organising department: Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS)
Organiser: Doris Chan (Kennedy Institute of Rheumatology)
Organiser contact email address: doris.chan@kennedy.ox.ac.uk
Host: Professor Irina Udalova (Kennedy Institute of Rheumatology)
Part of: Kennedy Institute Seminars
Booking required?: Not required
Audience: Members of the University only
Editor: Doris Chan