Ageing is a major risk factor for many diseases, including neurodegenerative disorders and cancers. My research focuses on understanding how intestinal stem cells function in rodents with varying lifespans. Using comparative analyses between short-lived mice and long-lived naked mole rats, we have recently shown that adult stem cell activity varies significantly between these species. Mimicking the biology of naked mole rats has the potential to reverse age-related decline in tissue function in humans.