Epigenetic technologies to advance cancer detection and cancer biology
My laboratory is interested in understanding the chemical modifications of our genome, transcriptome, and proteome in human health and disease – cancer in particular – and translating this information into diagnostic and therapeutic opportunities that ultimately benefit patients. To do so, we use our unique expertise in chemical biology to develop cutting-edge technologies to decode the wealth of epigenetic information. Most notably, we developed TAPS, a revolutionary bisulfite-free and base-resolution direct sequencing method for DNA epigenetic modifications. We have further demonstrated the application of TAPS in cell-free DNA for accurate identification of early liver cancer and pancreatic cancer. Our ongoing efforts aim to establish a comprehensive human epigenetic tissue atlas, as well as develop single-cell epigenetic sequencing to study tumour heterogeneity. We are also developing novel RNA modification sequencing methods to decipher the epitranscriptome in cancer.
Date: 19 September 2023, 9:30 (Tuesday, -2nd week, Michaelmas 2023)
Venue: Wellcome Trust Centre for Human Genetics, Headington OX3 7BN
Venue Details: Room A&B
Speaker: Dr Chunxiao Song (Ludwig Institute for Cancer Research, University of Oxford)
Organiser: Dr Ricardo Fernandes (CAMS Oxford Institute, University of Oxford)
Organiser contact email address: coi.admin@ndm.ox.ac.uk
Part of: CAMS Oxford Institute Seminars
Booking required?: Not required
Booking url: https://us02web.zoom.us/j/85069685687
Cost: free
Audience: Members of the University only
Editor: Natalie Baker