Recent advances in Cryo-EM structure determination
Cryo-EM single particle analysis is undergoing rapid changes. In this
talk, I will discuss how developments in sensitive and fast direct
electron detectors yield movies with relatively high signal-to-noise
ratios, and how new image processing techniques to deal with
beam-induced motions and structurally heterogeneous samples are now
yielding near-atomic resolution reconstructions for a wide range of
specimens. I will illustrate the potentials of these methods by
highlighting our recent results on various structures of human
gamma-secretase, the intramembrane protease complex responsible for
cleavage of amyloid precursor protein.
Date: 13 November 2015, 11:00 (Friday, 5th week, Michaelmas 2015)
Venue: Wellcome Trust Centre for Human Genetics, Headington OX3 7BN
Venue Details: Meeting Room B
Speaker: Dr Sjors Scheres (MRC Lab of Molecular Biology, Cambridge )
Organising department: Division of Structural Biology
Organiser: Eleanor Martin (Wellcome Trust Centre for Human Genetics)
Organiser contact email address: jones-pa@strubi.ox.ac.uk
Hosts: Prof E.Yvonne Jones (University of Oxford), Prof David Stuart (University of Oxford)
Part of: Strubi seminars
Booking required?: Not required
Audience: Members of the University only
Editors: Eleanor Martin, Agata Krupa