Nuclear actin dynamics and androgen receptor signalling

Our research at CIBSS aims at understanding the regulation and functions of the nuclear actin cytoskeleton in mammalian cells. We recently identified dynamic nuclear actin assembly during cell division. These actin filaments appear to facilitate nuclear growth and chromatin reorganisation, an essential process for proper genome organization and cell function during mitosis. Work in our laboratory aims at further elucidating the molecular players and mechanisms as well as the functional consequences for nuclear organization and cellular behavior.