Pivotal roles for type 2 immunity in epithelial immune surveillance
A high number of lymphocytes constitutively associate with epithelial tissues and these are called intraepithelial lymphocytes (IELs). IELs are not restricted to classical MHC and often express  T cells receptors (TCRs). In this talk, I will discuss the capacity of  TCR+ IELs in the skin to directly sense the health status of epithelial cells and to initiate a multifaceted response to promote homeostasis and tissue repair.

By a variety of means IELs cross-communicate with epithelial cells to regulate their proliferation, differentiation, transit time through the epidermis and even DNA repair. I will particularly focus on the importance of type 2 immunity in mediating immune-surveillance and will address how IL-33 contributes to skin homeostasis via regulation of tissue-resident Treg.

Overall, the talk will provide novel information on the versatile regulation of epithelial cells by type 2 immunity which ultimately strengthens the epithelial barrier and decreases susceptibility to damage and cancer development.
Date: 12 March 2024, 9:30 (Tuesday, 9th week, Hilary 2024)
Venue: Wellcome Trust Centre for Human Genetics, Headington OX3 7BN
Venue Details: Room A+B
Speaker: Professor Jessica Strid (Imperial College London)
Organisers: Dr Ricardo Fernandes (CAMS Oxford Institute), Dr Dannielle Wellington (CAMS Oxford Institute), Mimie Szyk (CAMS Oxford Institute)
Part of: CAMS Oxford Institute Seminars
Booking required?: Not required
Audience: Members of the University only
Editor: Mimie Szyk