Cross-regulation between the immune system and the extracellular matrix during lung pathology
In person only
Communication between our immune system and the ECM is essential for tissue health and when dysregulated can be a factor contributing to pathology. In conditions like asthma, inflammation is often a predictor of disease severity. However, our lab has shown that allergen-induced ECM remodelling still occurs in the absence of chronic inflammation. Rather, we have discovered ECM changes are induced and sustained by chitinase-like proteins, immune-associated molecules highly upregulated in inflammatory and fibrotic diseases. More broadly, we have begun to study spatial changes of key immune cells/mediators and ECM organisation in the lung to understanding immune-ECM crosstalk during disease.
Date:
18 March 2024, 12:00 (Monday, 10th week, Hilary 2024)
Venue:
Kennedy Institute of Rheumatology, Headington OX3 7FY
Venue Details:
Bernard Sunley Lecture Theatre
Speaker:
Dr Tara Sutherland (University of Aberdeen)
Organising department:
Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS)
Organiser:
Doris Chan (Kennedy Institute of Rheumatology)
Organiser contact email address:
doris.chan@kennedy.ox.ac.uk
Host:
Professor Kim Midwood (Kennedy Institute of Rheumatology)
Part of:
Kennedy Institute Seminars
Booking required?:
Not required
Audience:
Members of the University only
Editor:
Doris Chan
