New mechanisms of auto inflammatory disease
Mutations in innate immune genes can cause inherited inflammatory diseases (autoinflammatory diseases), which are the focus for the Masters laboratory. This work involves identifying and validating the functional significance of novel genetic variants, and the pathways in which they fall. One particular pathway of interest is the inflammasome, with recent findings showing how mutations in the Pyrin inflammasome cause Pyrin Associated Autoinflammation with Neutrophilic Dermatosis (PAAND). Related work studied mutations in the NLRP1 and NLRP3 inflammasomes, and observations from these rare diseases was extended to the analysis of common diseases such as obesity/type 2 diabetes and inflammatory bowel disease. This work provides therapeutic outcomes for patients with severe autoinflammatory disease, and shows how innate immune pathways influence common inflammatory diseases.
Date: 5 December 2016, 12:00 (Monday, 9th week, Michaelmas 2016)
Venue: Kennedy Institute of Rheumatology, Headington OX3 7FY
Venue Details: Bernard Sunley Lecture Theatre
Speaker: Dr Seth Masters (Laboratory Head Inflammation Division The Walter and Eliza Hall Institute, Melbourne)
Organising department: Kennedy Institute of Rheumatology
Organiser: Gintare Kolesnikovaite (Kennedy Institute of Rheumatology)
Organiser contact email address: Gintare.Kolesnikovaite@kennedy.ox.ac.uk
Host: Prof Fiona Powrie (PROFESSOR OF MUSCULOSKELETAL SCIENCES AND DIRECTOR OF THE KENNEDY INSTITUTE)
Part of: Kennedy Institute Seminars
Booking required?: Not required
Audience: Members of the University only
Editor: Gintare Kolesnikovaite