Clonal and cellular dynamics of the antibody response
This is a hybrid event - with the speaker attending in-person and viewable on Teams.
The average affinity of specific antibodies increases dramatically over the course of an immune response. This increase is the result of a Darwinian process in which B lymphocytes undergo iterative cycles of random hypermutation of their immunoglobulin genes, followed by selective proliferation of clones bearing affinity-enhancing mutations. This evolutionary process takes place in highly dynamic microanatomical structures known as germinal centers, which arise within secondary lymphoid organs upon infection or immunization. Our work combines intravital multiphoton microscopy with mouse genetics to study how the dynamics of B and T lymphocytes within germinal centers shapes the evolution of the high-affinity antibodies that are crucial to protection from infectious disease.
Date: 25 May 2023, 13:00 (Thursday, 5th week, Trinity 2023)
Venue: MRC Weatherall Institute of Molecular Medicine, Headington OX3 9DS
Venue Details: WIMM Seminar Room
Speaker: Prof Gabriel D. Victora (The Rockefeller University)
Organising department: MRC Weatherall Institute of Molecular Medicine
Organiser: Yasmine Saito (Weatherall Institute, University of Oxford)
Organiser contact email address: seminar.admin@imm.ox.ac.uk
Host: Dr Oliver Bannard (University of Oxford)
Part of: WIMM THURSDAY SEMINARS
Booking required?: Required
Booking email: seminar.admin@imm.ox.ac.uk
Audience: Members of the University only
Editors: Nicole Harris, Yasmine Saito