Neurogenesis factors as biomarkers of cognitive ageing and dementia
Age-related declines in stem cell function in the body and central nervous system of rodents can be reversed by exposure to a youthful systemic milieu. Conversely, the old milieu inhibits stem cell function in young rodents. In this study, allogeneic human serum from old healthy individuals induced an increase in apoptotic cell death of human hippocampal progenitor cells when compared to serum from young subjects. General Linear Models revealed variability in markers of proliferation and differentiation was partly attributable to intake of antihypertensive medication and very mild cognitive decline among older subjects. An endophenotype approach revealed upregulation of established and novel ageing molecular hallmarks in response to old serum following whole-genome expression arrays. interestingly, serum from older subjects induced a wide range of cellular and molecular phenotypes, likely reflecting the cumulative effect of health exposures and inequalities during a lifetime. Data will also be presented on how serum of mild cognitively impaired patients differentially alters human hippocampal progenitor cell fate to predict conversion to Alzheimer’s Disease.
Date:
22 June 2018, 12:00
Venue:
Le Gros Clark Building, off South Parks Road OX1 3QX
Venue Details:
Lecture Theatre
Speaker:
Prof Sandrine Thuret (King's College London)
Organising department:
Department of Physiology, Anatomy and Genetics (DPAG)
Organiser:
Francis Szele (DPAG, University of Oxford)
Organiser contact email address:
francis.szele@dpag.ox.ac.uk
Topics:
Booking required?:
Not required
Audience:
Members of the University only
Editor:
Francis Szele
