UCB Seminar: Antibody-enabled small molecule drug discovery
A networking lunch will be provided after the seminar - please join us! Please register for the seminar - only 40 places available.
We are pleased to welcome Dr Alastair Lawson, Senior Fellow from UCB for a seminar on ‘Antibody-enabled small molecule drug discovery’.

The seminar will be hosted by Paul Bowness – Professor of Experimental Rheumatology – Nuffield Department of Orthapaedics, Rheumatology and Musculoskeletal Sciences (NDORMS).

Alastair Lawson has been closely involved with the discovery of UCB/Celltech’s therapeutic antibodies for some thirty-five years, with Mylotarg®, Besponsa®, Cimzia® and Evenity® FDA-approved, and bimekizumab, dapirolizumab pegol and rozanoloxizumab in clinical trials. Alastair led the development of UCB’s proprietary antibody variable region discovery platform, and is now applying structure-based, rational design to antibody discovery. He pioneered UCB’s small molecule protein/protein interaction initiative, in which information derived from antibodies is applied to the discovery and design of new chemical entities. Current research interests include the use of function-modifying antibody fragments to define specific conformations of target proteins, linking X-ray crystallography, orthogonal biophysical techniques, molecular dynamics simulations and antibody technology to small molecule fragment screening.

Alastair’s seminar will cover: – Targeting protein-protein interactions with antibodies and small molecules – Conformational definition of target proteins with function-modifying antibodies – Allosteric modulation of target dynamics – Fragment library design and screening against defined conformations – Properties of small molecules
Date: 29 May 2019, 12:00 (Wednesday, 5th week, Trinity 2019)
Venue: Innovation Building
Venue Details: BioEscalator Meeting Rooms (1,2&3)
Speaker: Dr Alastair Lawson (Senior Fellow, UCB)
Organising department: Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS)
Organisers: Dr Charlotte Bell (University of Oxford), Prof Paul Bowness (Professor of Experimental Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences)
Organiser contact email address: charlotte.bell@medsci.ox.ac.uk
Host: Prof Paul Bowness (Professor of Experimental Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences)
Topics:
Booking required?: Required
Booking url: https://www.eventbrite.co.uk/e/ucb-seminar-antibody-enabled-small-molecule-drug-discovery-tickets-60920675380
Cost: Free
Audience: Public
Editor: Charlotte Bell