Hagan Bayley is the Professor of Chemical Biology at the University of Oxford. His research lies at the interface between chemistry and biology. Using protein chemistry, organic chemistry, and biophysics, his lab explores the folding, assembly, and function of transmembrane channels and pores. Stemming from these findings, his lab also develops engineered protein nanopores for applications in biotechnology including stochastic sensing, ultrarapid biopolymer sequencing and single-molecule covalent chemistry. More recently, the Bayley lab has developed techniques for fabricating 3D tissues, both living and synthetic. Professor Bayley will describe both the history of these developments as well as recent advances.