Trials within a cohort: a solution to key methodology issues?
To book a place, please email: octrutrialshub@ndorms.ox.ac.uk
Although randomisation ensures the elimination of selection bias the ‘standard’ two armed trial is not without its difficulties. Many participants have a treatment preference, which can introduce post-randomisation bias. Attrition is a problem in most trials with 20% or more attrition not being uncommon. Similarly trials can be slow and expensive.
A TWICs design can potentially address some of these problems. Essentially a TWIC is a RCT that is embedded within a larger cohort. Elements of the design can mean that attrition is lower, participant preferences are dealt with, costs are lowered due to the use of unequal allocation and existing cohorts. In this talk I will discuss the basic elements of the design and the experience of the York Trials Unit in its use.
Date:
2 December 2016, 13:00 (Friday, 8th week, Michaelmas 2016)
Venue:
Botnar Research Centre, Headington OX3 7LD
Venue Details:
G54
Speaker:
Professor David Torgerson (York Trials Unit)
Organising department:
Oxford Clinical Trials Research Unit
Organiser:
Emma Haines (University of Oxford, Nuffield Dept of Orthopaedics Rheumatology and Musculoskeletal Sciences)
Organiser contact email address:
octrutrialshub@ndorms.ox.ac.uk
Part of:
OCTRU/CSM Seminar Series
Booking required?:
Recommended
Booking email:
octrutrialshub@ndorms.ox.ac.uk
Audience:
Members of the University only
Editor:
Emma Haines
