Developmental Mechanisms in Schizophrenia
Brain development is a tremendously complex process in which a myriad of neuronal and non-neuronal cell types is generated and assembled into functional circuits in a highly organized manner. Many psychiatric disorders arise when developmental processes are perturbed by various genetic and environmental factors. Given high cellular diversity in the brain, for most psychiatric disorders, we are still far from understanding how they arise and what types of neurons and circuits underlie functional impairments in psychiatric disorders. Recent technological advance in single-cell analysis allowed us to address how psychiatric risk factors perturb brain development at single-cell resolution. In my presentation, I will show recently published and unpublished data from my lab, where we implemented single-cell analysis to identify how neuronal subtypes and their networks are perturbed during brain development in schizophrenia risk factor models, followed up by functional experiments to validate single-cell data.
Date: 3 February 2025, 15:00
Venue: Sherrington Building, off Parks Road OX1 3PT
Venue Details: Florence Buchanan Lecture Theatre
Speaker: Professor Konstantin Khodosevich (University of Copenhagen)
Organising department: Department of Physiology, Anatomy and Genetics (DPAG)
Organiser: Professor Zoltan Molnar (DPAG, University of Oxford)
Organiser contact email address: zoltan.molnar@dpag.ox.ac.uk
Host: Professor Zoltan Molnar (DPAG, University of Oxford)
Part of: Neuroscience Theme Guest Speakers (DPAG)
Booking required?: Not required
Audience: Members of the University only
Editor: Hannah Simm