Understanding how alterations in cortical circuitry modify behavioral outputs
CELLULAR & SYSTEMS NEUROSCIENCE
My lab aims at understanding the cellular and molecular underpinnings of neuropsychiatric symptoms and epilepsy resulting from alterations in cortical development. We have focused on a neurodevelopmental disorder Tuberous Sclerosis Complex (TSC). TSC is an autosomal dominant multisystem disorder occurring in 1/6,000 individuals with mutations in TSC1 or TSC2 leading to malformation of cortical development associated with seizures and worsening of cognitive and psychiatric deficits. The ultimate goal is to find treatments for preventing or rescuing the anatomical defects and associated symptoms.
Most of our work is performed in vivo using a combination of sophisticated tools including in utero electroporation combined with EEG recordings in adult mice, patch clamp electrophysiology, translating ribosome affinity purification followed by microarray, behavioral assessment, and the use of conditional system based on tamoxifen injections. Through these precise approaches, we have recently generated a novel murine model of focal cortical malformations that are associated with social deficits and can be generated with or without daily convulsive seizures. This model opens the door for uncovering the anatomical, biochemical, and electrophysiological defects associated with behavioral symptoms.
Date:
10 September 2015, 16:00 (Thursday, 20th week, Trinity 2015)
Venue:
Le Gros Clark Building, off South Parks Road OX1 3QX
Venue Details:
Large Lecture Theatre
Speaker:
Prof Angelique Bordey, PhD, Professor of Neurosurgery and of Cellular and Molecular Physiology (Neurosurgery, Yale School of Medicine, USA)
Organising department:
Department of Physiology, Anatomy and Genetics (DPAG)
Organiser:
Professor Zoltan Molnar (DPAG, University of Oxford)
Organiser contact email address:
zoltan.molnar@dpag.ox.ac.uk
Host:
Professor Zoltan Molnar (DPAG, University of Oxford)
Part of:
Neuroscience Theme Guest Speakers (DPAG)
Booking required?:
Not required
Audience:
Members of the University only
Editor:
Sara Bouskela
