Immune Checkpoint Deficiencies in Large Vessel Vasculitis
Dr. Weyand has a special interest in tissue-damaging immune responses in rheumatoid arthritis and large vessel vasculitis. She and her collaborators have established several preclinical models of autoimmune inflammation, including a chimera model in which human synovial tissue and human blood vessels are engrafted into immunodeficient mice. In these model systems, Dr. Weyand’s research team has defined the role of T cells and dendritic cells in deviating from protective to destructive immunity. Over the last decade, she has devoted special emphasis to the remodeling of the immune system with aging, how chronic disease ages the immune system, and how aged immune cells cause inflammation. This studies have identified molecular defects in metabolic programming and in DNA damage responses that render T cells tissue-invasive and pro-inflammatory. In recent work, she and her team have implicated defects in immuno-protective checkpoints in the breakdown of the arterial wall immunoprivilege, connecting the overall threshold setting of the immune system to organ-specific autoimmune disease.
Date: 6 September 2017, 10:00 (Wednesday, 20th week, Trinity 2017)
Venue: Kennedy Institute of Rheumatology, Headington OX3 7FY
Venue Details: Bernard Sunley Lecture Theatre
Speaker: Cornelia M. Weyand, MD, PhD (Chief, Division of Immunology and Rheumatology Professor of Medicine Stanford University)
Organising department: Kennedy Institute of Rheumatology
Organiser: Gintare Kolesnikovaite (Kennedy Institute of Rheumatology)
Organiser contact email address: Gintare.Kolesnikovaite@kennedy.ox.ac.uk
Part of: Kennedy Institute Seminars
Booking required?: Not required
Audience: Members of the University only
Editor: Gintare Kolesnikovaite