Evolution of the Cancer Genome
In recent years there has been an explosion in both the amount of next-generation sequencing performed on cancers and in the number of computational methods used to analyse the generated data. Focusing on cancer evolution and heterogeneity, I describe the findings of my research through both large-scale projects such as the International Cancer Genome Consortium and smaller-scale studies of individual tumour types, including prostate, oesophageal, colorectal, breast and haematological cancers. These findings cover a range of topics, including: progression from benign neoplasms to cancer; mechanisms of metastatic spread; changes in mutational processes during cancer progression; variable subclonal response to treatment; the importance of the order of acquisition of driver mutations.
Date: 22 June 2017, 11:00 (Thursday, 9th week, Trinity 2017)
Venue: NDM Building, Headington OX3 7FZ
Venue Details: TDI, Basement meeting room, NDM Research Building
Speaker: Dr David Wedge (Big Data Institute)
Organising department: Ludwig Institute for Cancer Research, Oxford Branch
Organiser: Mary Muers (Oxford Ludwig Institute, NDM Experimental Medicine)
Organiser contact email address: mary.muers@ludwig.ox.ac.uk
Host: Dr Gareth Bond (Ludwig Cancer Research, University of Oxford)
Part of: Ludwig Institute Seminar Series
Booking required?: Not required
Audience: Members of the University only
Editors: Mary Muers, Christina Woodward