MitOX


Venue: This event will be hybrid. It will take place on Zoom and in-person attendance will take place in the Academic Block at the John Radcliffe Hospital, Oxford OX3 9DU When we know more about the allowed numbers for in-person attendance due to COVID-19 guidelines, we will be launching an option for registering face to face (there will be a registration charge of £30 for those attending in person).

The Nuffield Department of Women’s & Reproductive Health invites you to MitOX 2022 on Friday 8th April 2022. It’s our annual meeting packed with short talks and posters on cancer metabolism, neuroscience, diabetes, mitochondrial disorders and general mitochondrial biology. This one day hybrid conference is ideal for researchers with an interest in mitochondria from both academia and pharma. It will include a range of short talks and posters on cancer metabolism, neuroscience, diabetes, mitochondrial disorders and general mitochondrial biology.

9.00 Karl Morten (Oxford) Welcome
9.05 Mitochondrial DNA, expression and recombination: Chair Jo Poulton (Oxford)
9.05 Dan Mishmar (Israel) The impact of mitochondrial gene expression regulation, and its coordination with the nucleus, on disease
9.30 Ana Victoria Lechuga-Vieco (Oxford) Mitochondrial heterogeneity: friend or foe?
9.55 Yizhou Yu (Cambridge) Parp mutations protect from mitochondrial toxicity in Alzheimer’s disease
10.10 Hansong Ma (Cambridge) A meiotic helicase drives recombination to safeguard animal mitochondrial genomes

10.35 Coffee Break

11.00 Cancer: Chair Rhiannon McGeehan (Portsmouth)
11.00 Payam Gammage (Glasgow) The impact of cancer-associated mtDNA mutations on tumour metabolism and the microenvironment
11.25 Markus Ralser (The Crick) The metabolic growth limitations of petite cells lacking the mitochondrial genome
11.50 Nuno Santos Leal (Cambridge)Contacts between mitochondria and the endoplasmic reticulum protect from mitochondrial toxicity by activating the PERK/ATF4 branch of ER stress
12.05 Mike Duchen (UCL) Rewiring cell signalling pathways in pathogenic mtDNA mutations
12.30 Sponsors Talks BMG Labtech, Promega, Agilent, Atlantic imaging

13.00 Lunch & Poster session I

14.00 Katharina Schlacher (Texas) BRCA/FANC tumor suppressor roles in mitochondrial genome instability and inflammation.
1425 Mitophagy and Dynamics: Chair Tom Nichol (Oxford)
14.25 Pollard Lecture William Mair (Harvard) Metabolic Flexibility, Mitochondrial Dynamics & Healthy Aging
15.05 Brent Ryan (Oxford) Integrating animal and cellular models to understand mitochondrial dysfunction in Parkinson’s disease

15.20 Tea & Poster Session II

16.00 Mitochondrial medicine: Chair Kerstin Timm (Oxford)
16.00 Leanne Hodson (Oxford) Tracing fat to determine factors influencing mitochondrial fatty acid oxidation in human
16.25 Lisa Heather (Oxford) Diabetic cardiac mitochondria are resistant to the regulation of respiration by lipid intermediates
16.50 Robin Klemm (Oxford) Mechanisms controlling de novo lipogenesis based lipid droplet expansion during adiopcyte differentiation”
17.15 Isabella Panfoli (Genova) The polyphenol Cirsiliol prevents the light-induced oxidative damage of the retinal rod outer segment in vitro

17.30 Close Poster prizes