Biological roles of hematopoietic niches in the origination and development of leukemia
This is a hybrid event - with the speaker attending in-person and viewable on Teams.
My group studies biological roles of hematopoietic niches in the origination and development of leukaemia, making effort to address two issues of pathogenesis and therapeutics of the disease. First, how developmental tissue microenvironments provide genome protection for hematopoietic
tem and progenitor cells (HSPCs) and how the native lack or pathological loss of protection results in NDA damage and genome instability in HSPCs when encountering endogenous, e.g. metabolic, or exogenous genotoxic agents and leukaemia initiation. Second, how leukaemic microenvironments provide protective niches for leukaemic propagating cells in evading therapy including chemotherapy and immunotherapy. The aims of these studies are to identify and characterise the niche cells and molecules that are involved in leukaemia initiation and development and that can be targeted for disease prevention and future therapies. We have recently identified a leukaemogenic niche in the foetal liver and several therapyinduced niches in the leukaemic bone marrow. In the seminar talk I will share these interesting findings.
Date: 3 August 2023, 12:00 (Thursday, 15th week, Trinity 2023)
Venue: MRC Weatherall Institute of Molecular Medicine, Headington OX3 9DS
Venue Details: Seminar Room
Speaker: Professor Dengli Hong (Shanghai Jiao Tong University School of Medicine)
Organising department: MRC Weatherall Institute of Molecular Medicine
Host: Tao Dong (University of Oxford)
Part of: WIMM THURSDAY SEMINARS
Booking required?: Not required
Booking email: seminar.admin@imm.ox.ac.uk
Audience: Members of the University only
Editor: Yasmine Saito